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KMID : 1011820210620020195
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Investigative and Clinical Urology
2021 Volume.62 No. 2 p.195 ~ p.200
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A high basal metabolic rate is an independent predictor of stone recurrence in obese patients
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Kang Ho-Won
Seo Sung-Pil
Lee Hee-Youn
Kim Kyeong
Ha Yun-Sok
Kim Won-Tae
Kim Yong-June
Yun Seok-Joong
Kim Wun-Jae
Lee Sang-Cheol
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Abstract
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Purpose: Basal metabolic rate (BMR) is an indicator of overall body metabolism and may portend unique aberrations in urine physico-chemistry and stone recurrence. The present study examined the effect of predicted BMR on 24 hours urinary metabolic profiles and stone recurrence in obese stone patients.
Materials and Methods: Data from 308 obese patients (body mass index [BMI] ≥30 kg/m2) diagnosed with urinary stone disease between 2003 and 2015 were analyzed retrospectively. BMR was calculated using the Harris?Benedict equation, and patients were classified into two predicted BMR categories (<1,145 kcal/day, ≥1,145 kcal/day). Urinary metabolic parameters and risk of stone recurrence were compared between the two groups.
Results: The high BMR group was more likely to be younger and female, and to have a high BMI and lower incidence of diabetes than the low BMR group (each p<0.05). There was a positive correlation between BMR and 24 hours urinary sodium, uric acid, and phosphate excretion. The amounts of stone-forming constituents such as calcium and uric acid were significantly higher in the high BMR group. Kaplan?Meier estimates showed that the high BMR group had a significantly shorter stone recurrence-free period than the low BMR group (log-rank test, p<0.001). Multivariate Cox regression analyses revealed that predicted BMR was an independent factor of stone recurrence (hazard ratio, 2.759; 95% confidence interval, 1.413?5.386; p=0.003).
Conclusions: BMR may be an easily measured parameter that can be used to identify risk of stone recurrence in obese stone patients.
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KEYWORD
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Basal metabolism, Obesity, Recurrence, Urinary calculi
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